EP 17 : Liver Health and Detoxification with Dr. Satish Nadig

Summary

Dr. Satish shares his life journey and how he became passionate about transplantation. He discusses the importance of liver health and the role of the liver as the main detoxifier in the body. He explains the concept of detoxifying the liver and the use of rapamycin as a potential geroprotector. Satish also talks about the early stages of liver damage, including fatty liver disease. The conversation explores the progression of liver disease, from fatty liver to cirrhosis and end-stage liver disease. It discusses the impact of alcohol and other factors on liver health, as well as the development of new treatments and technologies in the field of liver transplantation. The story of a patient who underwent a liver transplant is shared as an example of the transformative power of medical intervention.

Takeaways

- Satish's life journey has been driven by his passion for transplantation and making an impact in the field.

- The liver plays a crucial role in detoxifying the body and maintaining overall health.

- Rapamycin, an mTOR inhibitor, shows potential as a geroprotector and has been linked to increased longevity and improved immune function.

- Early stages of liver damage, such as fatty liver disease, can be prevented and managed through lifestyle changes and proper medical care. Liver disease can progress from fatty liver to cirrhosis and end-stage liver disease, with serious health consequences.

- Alcohol is a major contributor to liver disease, but other factors such as obesity and metabolic dysfunction can also play a role.

- New treatments and technologies, such as cellular therapy and targeted nanotherapy, show promise in improving outcomes for liver transplant patients.

- Liver transplantation is a life-saving option for individuals with end-stage liver disease, but the need for donor organs remains a challenge.

- The story of a patient who underwent a liver transplant highlights the transformative impact of medical intervention in restoring health and quality of life.

Chapters

00:00 Satish's Life Journey and Passion for Transplantation

07:17 The Importance of Liver Health and Detoxification

11:37 Detoxifying the Liver and the Role of Rapamycin

18:11 Rapamycin as a Geroprotector and its Effects on Immune Function

23:31 Understanding mTOR and its Role in Health and Disease

26:42 Understanding Liver Disease: From Fatty Liver to Cirrhosis

31:23 The Impact of Alcohol and Other Factors on Liver Health

33:13 Advancements in Treating Fatty Liver Disease

38:46 The Therapeutic Option of Liver Transplantation

41:05 The Next Era of Liver Transplantation: Advancements in Technology

44:45 The Transformative Power of Liver Transplantation: A Patient's Story

Dr. Satish Links

Tedx Talk : https://youtu.be/q41mHl71vSY?si=t4I_TJQ7Fh1LaeuM

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