In this episode of the Dementia Researcher Podcast, guest host Dr Fiona McLean is joined by Dr Josh Harvey (University of Exeter), Dr Sarah Marzi (King’s College London), Dr Alexi Nott (Imperial College London), and Dr Sam Washer (Wellcome Trust Sanger Institute) to discuss the role of epigenetics in Alzheimer’s and dementia research. The episode offers a broad exploration of epigenetics in neurodegenerative diseases, highlighting how gene regulation beyond DNA sequences is advancing our understanding of Alzheimer’s and related conditions. It covers the impact of environmental and lifestyle factors on disease development, as well as emerging research techniques and technologies that could inform future diagnostic and therapeutic approaches. -- Key Topics: • The fundamentals of epigenetics and its distinction from traditional genetics. • How epigenetic research is shaping our understanding of Alzheimer's disease. • The role of environmental factors in influencing epigenetic changes. • New technologies and their application in epigenetic studies. • The potential for epigenetics in developing future diagnostics and therapies for neurodegenerative diseases. -- Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you’ll find a video version of this podcast with a transcript on our website. -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on social media: http://www.instagram.com/dementia_researcher/ http://www.facebook.com/Dementia.Researcher/ http://www.twitter.com/demrescommunity http://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social -- Download our new community app: https://onelink.to/dementiaresearcher

In this episode of the Dementia Researcher podcast, Dr Anna Volkmer leads a discussion on the importance of co-production in dementia research. This episode explores what it truly means to involve people with lived experience, with tips on how to go about it, and our guests own experience in working together. They also discuss the research process and how this approach can lead to more relevant and impactful outcomes. Featured Guests: •Dr Barbora Silarova: An NIHR / Alzheimer’s Society Dem Comm Fellow at the University of Kent. Barbora brings her expertise in supporting people living with dementia and their carers. She shares insights on the significance of equal partnerships in co-produced research and the challenges and rewards of this collaborative approach. •Dr Rosie Ashworth: A researcher who leads patient and public involvement for the NRS Neuroprogressive and Dementia Network in Scotland. Rosie discusses the importance of involving those with lived experience in research to enrich the quality and relevance of scientific findings. •Winnie Henry: A retired psychotherapist who cared for her husband with vascular dementia. Winnie provides a personal perspective on the value of co-production, emphasising empathy and the importance of ensuring that carers' voices are heard in research. •Mike Parish: A retired firefighter who became a carer for his husband, who had progressive supranuclear palsy. Mike highlights the importance of representing diverse experiences and backgrounds in dementia research to ensure all voices are considered. •David Ross: A retired engineer who cared for his wife with frontotemporal dementia. David speaks about his journey into co-production, driven by a desire to understand more about dementia and contribute to meaningful research that reflects the realities faced by carers. -- Essential links / resources mentioned in the show: NHS England Co-production resource toolkit https://www.england.nhs.uk/publication/co-production-resource-toolkit/ Co-Production Collective https://www.coproductioncollective.co.uk/ The Dementia Enquirers Gold Standards for Co-Research https://dementiaenquirers.org.uk/wp-content/uploads/2023/02/gold-standard-for-co-research.pdf DEEP Network - A Story of Co-Production https://www.dementiavoices.org.uk/wp-content/uploads/2020/07/A-story-of-co-production-%E2%80%93-The-Right-to-a-Grand-Day-Out.pdf -- Together, these guests provide valuable insights into the process and benefits of co-produced research, offering practical tips for researchers looking to adopt this approach. Tune in to learn more about how prioritising people can transform the way we approach dementia research. -- Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you’ll find a video version of this podcast with a transcript on our website. -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on social media: http://www.instagram.com/dementia_researcher/ http://www.facebook.com/Dementia.Researcher/ http://www.x.com/demrescommunity http://www.linkedin.com/company/dementia-researcher http://www.bsky.app/profile/dementiaresearcher.bsky.social

In this episode of the Dementia Researcher Podcast, we discuss the challenges and support needs of early career dementia researchers (ECRs) across Europe. Our discussion centres on a recent study titled Supporting Early Career Dementia Researchers: Identifying Support Needs and Ways Forward via a European Study. The study sheds light on the unique difficulties faced by ECRs and offers practical recommendations to enhance professional journeys. -- Speakers: 🔹Adam Smith: Programme Director for Dementia Researcher and today's guest host. 🔹Dr Charlèss Dupont: A postdoctoral researcher at Freie University in Brussels with a background in nursing and communication. Charlès's work primarily focuses on communication and palliative care in dementia. 🔹Dr Pascale Heins: With a background in occupational therapy, Dr. Heins works at Maastricht University, where her research explores ways to support social life in people with dementia. 🔹Dr Sara Laureen Bartles: A postdoctoral researcher at Karolinska Institutet in Stockholm and Maastricht University, Sarah's research spans chronic conditions management, including dementia. -- Key Takeaways: 🔹Funding and Career Support: The study identifies a significant need for better financial support mechanisms, particularly in the transition from PhD to postdoctoral roles. 🔹Work-Life Balance: The pressures of academia often lead to an unhealthy work-life balance, with expectations set by supervisors. The study calls for more proactive support from institutions. 🔹Mentoring and Training: The importance of mentoring and training, both within academia and for careers outside of it, is emphasised as a way to better prepare researchers for diverse career paths. 🔹Dissemination: There is a need for improved dissemination strategies, ensuring that research findings reach a broader audience, including those directly affected by dementia. Tune-in as we explore these critical issues and discuss actionable solutions to support the current and next generation of dementia researchers. -- Essential links / resources mentioned in the show: Supporting early-career dementia researchers: Identifying support needs and ways forward via a European study - https://bit.ly/3WN1yju How are early-career dementia researchers considered and supported on a national level by dementia plans and organizations? An overview of global policy approaches - https://bit.ly/3YMxrLq ISTAART and University College London survey turns a spotlight on early career researcher life and challenges - https://bit.ly/4dMmoWK Join ISTAART - istaart.alz.org Pascal's PhD Defence - https://www.youtube.com/watch?v=CDjURgVH6YM -- Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you see? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to listen rather than listen, you’ll find an audio version of this podcast with a transcript on our website. -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on social media: http://www.instagram.com/dementia_researcher/ http://www.facebook.com/Dementia.Researcher/ http://twitter.com/demrescommunity http://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

In this podcast we share a few selected highlights from the last day of the Alzheimer’s Association International Conference (AAIC) taking place in Philadelphia and Online, 28th July to 1st August. Quang Tran, Science Communications Officer for Alzheimer's Research UK, guest hosts the show with expert panelists: Dr Shea Andrews, Assistant Professor at University of California San Francisco working on Genetic Epidemiology of Alzheimer’s disease. Dr Joe Butler, NIHR ARC Research Fellow at University of Sunderland, interested in using techniques and paradigms from experimental psychology to learn about brain health. Roberto A. Guzmán Hernández, ISTAART Ambassador, Graduate Research Assistant and PhD Student at Temple University working on the effects of aggregated tau on endothelial and cerebrovascular dysfunction -- The AAIC brings together distinguished basic scientists, clinical researchers, early career investigators, clinicians and the care research community at the largest and most influential international conference on dementia science. They share theories and breakthroughs while exploring opportunities to accelerate work and elevate careers. Main plenary talks from the day included Michael Weiner 'ADNI: Two Decades Of Impact And The Path Forward', Reisa Sperling ' Preclinical Alzheimer’s Disease'. Today was also the first AAIC For ALL, a new format with talks for professional from Jeffrey Cummings on the Therapeutic Landscape, Heather Whitson on The Role Of Blood Tests In Diagnosis And Treatment, Clifford Jack on Criteria For Diagnosis And Staging, Monica Rivera-Mindt on Health Equity And Risk Reduction and Katherine Possin on Dementia Care. Talks for a lay audience from Edward B. Lee on Brain Donation: The Gift Of Knowledge, Hussein Zalzale on The Many Faces Of Alzheimer’s Dementia, Subtypes And Unique Features, Dawn Mechanic-Hamilton on How Can We Improve Cognitive Testing? The Answer May Be In The Palm Of Your Hand, Cerise Elliot on Building Inclusive Alzheimer’s And Related Dementias Research Studies, Wiesje van der Flier on 'Risk Reduction', Jonathan Schott on 'Diagnosis And Treatment', Nancy Hodgson on 'Dementia Care', Ozioma Okonkwo on 'Health Equity'. #AAIC24 -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

In this podcast we share a few selected highlights from the fourth day of the Alzheimer’s Association International Conference (AAIC) taking place in Philadelphia and Online, 28th July to 1st August. Dr Amanda Heslegrave, Principle Research Fellow at University College London, hosts the show with special guests: Dr Darina Petrovsky, Assistant Professor at Duke University Dr Emily Ho, Assistant Professor at Northwestern University Meenakshi Menon, ISTAART Ambassador and incoming PhD student in Cognitive Sciences at Georgia State University The AAIC brings together distinguished basic scientists, clinical researchers, early career investigators, clinicians and the care research community at the largest and most influential international conference on dementia science. They share theories and breakthroughs while exploring opportunities to accelerate work and elevate careers. Main plenary talks from the day included Tara Spires-Jones presenting on 'Synaptic Oligomeric Tau In Alzheimer’s Disease — A Potential Culprit In The Spread Of Tau Pathology Through The Brain ', Ricardo F. Allegri on 'Dementia Research In Low- And Middle-Income Countries: Initiatives That Seize Opportunities, Overcome Challenges And Build Capacity'. #AAIC24 -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

In this podcast we share a few selected highlights from the third day of the Alzheimer’s Association International Conference (AAIC) taking place in Philadelphia and Online, 28th July to 1st August. Caitlyn Fastenau,  PhD Candidate at University of Texas Health San Antonio, hosts the show with special guests: Balogun Wasiu, Postdoctoral Associate at University of Pittsburgh Jessica Caldwell, Director, Women’s Alzheimer’s Movement Prevention and Research Center, Cleveland Clinic Sophia Krix, PhD Student at University of Bonn, working on the ADIS Project The AAIC brings together distinguished basic scientists, clinical researchers, early career investigators, clinicians and the care research community at the largest and most influential international conference on dementia science. They share theories and breakthroughs while exploring opportunities to accelerate work and elevate careers. Main plenary talks from the day included Suvarna Alladi 'Bilingualism And Dementia: Implications For Brain Health And Policy Development', Clive Ballard on 'Psychosis In Alzheimer’s Disease'. #AAIC24 -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

In this podcast we share a few selected highlights from the first two days of the Alzheimer’s Association International Conference (AAIC) taking place in Philadelphia and Online, 28th July to 1st August. Dr Francesca Farina hosts the show with special guests: Dr Annalise Rahman-Filipiak, Assistant Professor, Clinical Neuropsychologist at University of Michigan Dr Tamlyn Watermeyer, NIHR / Alzheimer’s Society Dem Comm Fellow at Northumbria University and University of Edinburgh working on cognition and brain health. Dr Merci Best, Research Fellow at the University of Michigan's Paulson Lab, studying the molecular mechanisms of tau-mediated neurodegeneration The AAIC brings together distinguished basic scientists, clinical researchers, early career investigators, clinicians and the care research community at the largest and most influential international conference on dementia science. They share theories and breakthroughs while exploring opportunities to accelerate work and elevate careers. Main plenary talks from the day included Edward B. Lee presenting 'Neuropathology In A Multidisciplinary Age', Timothy Miller on 'Antisense Oligonucleotide Therapeutics For Neurodegenerative Diseases', Henne Holstege delivering a talk titled 'From Longevity To Vulnerability: Genomic Pathways Underlying Cognitive Health In Centenarians And Neurodegenerative Disease'. #AAIC24 @alzassociation -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

Welcome to the last show in this season of the ISTAART PIA Relay Podcast, presented by Dementia Researcher. In our final episode, we come full circle with Dr Keir Yong, Senior Research Fellow at UCL's Dementia Research Centre, speaking with Professor Arlene Astell, Chair of the Non-Pharmacological Interventions PIA. -- Professor Astell discusses her role as a Professor of Cyber Psychology at Northumbria University and Director of the Dementia Ageing Technology Engagement Lab at the University of Toronto. She offers a comprehensive look into her journey into dementia research, sparked by early interactions with individuals living with dementia, and her commitment to understanding and mitigating the cognitive and behavioural challenges they face. -- Gain insights into the innovative projects led by Professor Astell, including the development of touchscreen computer systems designed to support conversation for people with dementia. How the significance of lifestyle interventions, such as nutrition and physical activity, and the emerging potential of neuromodulation can play a role in reducing dementia risk. -- The conversation also highlights the broader implications of non-pharmacological interventions, the challenges in implementing these approaches within health systems, and the importance of influencing public health policy to ensure wider adoption – and the role that the Non-Pharmacological Interventions PIA can play in fostering collaboration. -- The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) convenes the global Alzheimer’s and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer’s and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. -- There are currently 30 PIAs covering a wide range of interests and fields, from the PIA to Elevate Early Career Researchers to Biofluid Based Biomarkers and everything in between. To sign-up to ISTAART and a PIA visit: http://www.istaart.alz.org - Note: ISTAART Membership is free for students worldwide, and for researchers of all levels based in Low- and Middle-Income Countries. -- To book your place at this year’s AAIC (In-person and online) visit: http://www.aaic.alz.org -- You can also enjoy this show as a video on our YouTube Channel at: https://youtu.be/fF6oDHK_iP4 -- Find more information on our guests, and a full transcript of this podcast on our website at: https://www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

Join us for another episode of the ISTAART Relay Podcast brought to you by Dementia Researcher. We’re releasing one of these shows each week in the build up to the AAIC, which this year starts on the 28th July. In this episode, Dr Diana Karamacoska takes over the hot seat to interview Dr Keir Yong, a Senior Research Fellow at University College London, about the intricacies of Atypical Alzheimer's Disease, and the work of the Atypical Alzheimer's Disease PIA. Discover how posterior cortical atrophy (PCA), a less common variant of Alzheimer’s, impacts patients' lives and the innovative research aiming to improve diagnosis and treatment. Get insights into the diagnostic challenges, the role of biomarkers, and the essential interdisciplinary collaborations driving advancements in this field. Don't miss this deep dive into Keir’s work, hot topics in the field, and how their PIA is making a difference. -- The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) convenes the global Alzheimer’s and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer’s and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. -- There are currently 30 PIAs covering a wide range of interests and fields, from the PIA to Elevate Early Career Researchers to Biofluid Based Biomarkers and everything in between. To sign-up to ISTAART and a PIA visit: http://www.istaart.alz.org. Note: ISTAART Membership is free for students worldwide, and for researchers of all levels based in Low- and Middle-Income Countries. -- To book your place at this year’s AAIC (In-person and online) visit: http://www.aaic.alz.org -- You can also enjoy this show as a video on our YouTube Channel at: https://youtu.be/53wt10WyURI -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

Join us for another episode of the ISTAART Relay Podcast from Dementia Research. This time Dr Ece Bayram moves from interviewee to interviewer and chats with Dr Diana Karamacoska, the vice chair of the Partnering with Research Participants PIA. This episode explores the challenges and breakthroughs in dementia research, with a special focus on engaging underserved communities, and public involvement. Dr Karamacoska shares her personal journey inspired by her grandparents' experiences with dementia, highlighting the gaps in services and the importance of culturally appropriate care. -- Discover how the ISTAART PIAs are transforming dementia research through meaningful partnerships and inclusive practices. Learn about the global shift towards collaboration with research participants and the innovative approaches being used to address disparities in dementia care. Diana also discusses the significance of maintaining well-being while working closely with affected communities and the role of the PIA in supporting researchers. -- Tune in to explore the latest trends, including the exciting initiatives planned for the upcoming Alzheimer's Association International Conference (AAIC) in Philadelphia, and understand why the Partnering with Research Participants PIA is unique in its dedication to patient and public involvement. -- The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) convenes the global Alzheimer’s and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer’s and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. -- There are currently 30 PIAs covering a wide range of interests and fields, from the PIA to Elevate Early Career Researchers to Biofluid Based Biomarkers and everything in between. To sign-up to ISTAART and a PIA visit: http://www.istaart.alz.org - Note: ISTAART Membership is free for students worldwide, and for researchers of all levels based in Low- and Middle-Income Countries. -- To book your place at this year’s AAIC (In-person and online) visit: http://www.aaic.alz.org -- You can also enjoy this show as a video on our YouTube Channel at: https://youtu.be/g6bVYyhNFV8 -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

In this episode of the ISTAART Relay Podcast, Dr Jessica Caldwell, a neuropsychologist and director at the Cleveland Clinic, interviews Dr Ece Bayram, the newly appointed assistant professor and incoming communications chair for the ISTAART Lewy Body Dementias PIA. They explore Ece’s research on sex differences in genetics and environmental risk factors for Lewy body dementia. Ece shares insights into her innovative projects, the work of their PIA, plans for the upcoming AAIC and the significance of understanding sex and gender differences in neurodegenerative diseases, and the importance of designing research with community involvement. They also discuss the challenges of conducting studies in diverse populations and the need for global collaboration. Tune in to hear about the exciting developments in Lewy body dementia research and the impact of community-driven studies on advancing the field. -- The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) convenes the global Alzheimer’s and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer’s and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. -- There are currently 30 PIAs covering a wide range of interests and fields, from the PIA to Elevate Early Career Researchers to Biofluid Based Biomarkers and everything in between. To sign-up to ISTAART and a PIA visit: http://www.istaart.alz.org Note: ISTAART Membership is free for students worldwide, and for researchers of all levels based in Low- and Middle-Income Countries. -- To book your place at this year’s AAIC (In-person and online) visit: http://www.aaic.alz.org You can also enjoy this show as a video on our YouTube Channel at: https://youtu.be/psSB1wOGSxA -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

Welcome to the fifth season of the ISTAART PIA Relay Podcast, brought to you by Dementia Researcher. In this six-part series, members of ISTAART professional interest areas (PIAs) take turns interviewing their colleagues about the latest research in Alzheimer's disease and other dementias. This episode features a Caitlyn Fastenau, a PhD candidate from the University of Texas Health Science Centre interviewing Dr Jessica Caldwell, a neuropsychologist and director of the Women’s Alzheimer’s Movement Prevention and Research Centre at Cleveland Clinic. Dr Caldwell discusses her pioneering work at the world's only clinic designed specifically for women to reduce their Alzheimer's risk, focusing on sex and gender differences in the disease. She highlights the critical role of menopause, stress, and hormonal changes in Alzheimer's risk and shares insights into the importance of diverse research populations and the unique challenges faced by women caregivers. Tune-in as explore hot topics of sex and gender differences in Alzheimer's research, including the impact of menopause, the need for gender-diverse studies, and the initiatives of the ISTAART Sex and Gender PIA and what they have planned for AAIC. Whether you're a researcher, clinician, or someone affected by Alzheimer's, this episode offers valuable perspectives on the intersections of gender, health, and dementia. -- The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) convenes the global Alzheimer’s and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer’s and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. -- There are currently 30 PIAs covering a wide range of interests and fields, from the PIA to Elevate Early Career Researchers to Biofluid Based Biomarkers and everything in between. To sign-up to ISTAART and a PIA visit: http://www.istaart.alz.org Note: ISTAART Membership is free for students worldwide, and for researchers of all levels based in Low- and Middle-Income Countries. -- To book your place at this year’s AAIC (In-person and online) visit: http://www.aaic.alz.org You can also enjoy this show as a video on our YouTube Channel at: https://youtu.be/E0NWtCyJtzI -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

Welcome to the fifth season of the ISTAART PIA Relay Podcast, brought to you by Dementia Researcher. This series features members of ISTAART, engaging in insightful interviews about groundbreaking dementia research, and the work of the ISTAART Professional Interest Areas (PIA) they represent. As we build up to the Alzheimer’s Association International Conference in Philadelphia, join us for daily episodes that showcase the remarkable work being done in various research fields. -- In this episode, Professor Arlene Astell interviews Caitlyn Fastenau, a PhD candidate in Integrated Biomedical Sciences focusing on the Biology of Ageing. Caitlyn shares her journey into dementia research, driven by personal experiences and a passion for understanding neurodegenerative diseases. Her research explores the role of immune cells, particularly microglia, in Alzheimer’s disease, using advanced techniques like single-cell RNA sequencing. Caitlyn discusses the her work, the importance of diversity in research, highlighting efforts to include underrepresented communities in dementia studies. She also talks about the significance of translational research and the potential non-pharmacological interventions that could reduce the risk of neurodegenerative diseases. Tune in to learn more about the Immunity and Neurodegeneration PIA, what they have planned for AAIC and the latest hot topics in the field, and the collaborative environment that ISTAART provides for researchers at all levels. PS. Don't miss Caitlyn's presentation at the AAIC and her insights on leveraging student engagement in scientific societies. -- The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) convenes the global Alzheimer’s and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer’s and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. -- There are currently 30 PIAs covering a wide range of interests and fields, from the PIA to Elevate Early Career Researchers to Biofluid Based Biomarkers and everything in between. To sign-up to ISTAART and a PIA visit: http://www.istaart.alz.org Note: ISTAART Membership is free for students worldwide, and for researchers of all levels based in Low- and Middle-Income Countries. -- To book your place at this year’s AAIC (In-person and online) visit: http://www.aaic.alz.org -- You can also enjoy this show as a video on our YouTube Channel at: https://youtu.be/dddOpDsuwlM -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

Adam Smith chats with Dr Claire Sexton, Senior Director, Scientific Programs and Outreach from the Alzheimer’s Association. Discussing this year’s Alzheimer’s Association International Conference (AAIC) 28th July to 1st August (+preconference on the 25th – 27th). -- Taking place in-person in Philadelphia and online - the world’s leading basic scientists, clinical researchers, early career investigators, clinicians and the care research community will share breaking research discoveries that will lead to methods of prevention and treatment and improvements in diagnosis for Alzheimer’s disease. In this exciting edition, we will be giving you an exclusive sneak peek into one of the most highly anticipated events in dementia research conference calendar (also a world first exclusive on the location for 2025). Join us as we explore into how you can attend, the scientific programme, extra events and just what the AAIC will deliver this year. With leading experts, visionary thinkers, and research pioneers gathering under one roof, this conference promises to not only showcase groundbreaking discoveries, but also be a place where you will get careers support, and unrivalled networking opportunities. -- To book your place visit – http://www.aaic.alz.org AAIC for ALL - https://www.alz.org/aaic-for-all/overview.asp Dr Helena Gellersen’s blog on getting the most out of AAIC: https://www.dementiaresearcher.nihr.ac.uk/blog-ultimate-guide-to-making-the-most-of-the-aaic -- Students worldwide and researchers from Low- and Middle-Income Countries are now eligible for free ISTAART Membership (and ISTAART members can attend the AAIC Online for Free) - Become a member, then register for the conference if you can't make it in-person. Join ISTAART to get a free online ticket – http://www.istaart.alz.org -- Full biographies on all our guests and a transcript can be found on our website www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you’ll find a video version of this podcast with full captions on our YouTube Channel. -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Welcome to the Dementia Researcher Podcast. In this episode, Dr Fiona McLean, an Alzheimer's Research UK fellow at the University of Dundee, discusses the issue of academic burnout with three fellow researchers. The guests, Dr Sarah Marzi, Dr Ian Harrison, and Dr Kate Harris, share their personal experiences with burnout, its impact on their work and personal lives, and strategies for managing and preventing it. They highlight the importance of setting boundaries, seeking mentorship, maintaining a work-life balance, and practising self-kindness. They also emphasise the need for a supportive and sustainable research culture. -- Five Top Tips from the Show: 1. Set Boundaries: Establish clear boundaries in your work to manage expectations and workload effectively. Communicate these boundaries with your colleagues and superiors to ensure a sustainable work environment. 2. Seek Mentorship: Engage with mentors both within and outside your institution. Mentors can provide valuable guidance, support, and perspective, helping you navigate the challenges of academic life. 3. Maintain Work-Life Balance: Dedicate time to activities outside of work that bring you joy and relaxation, such as hobbies or exercise. This helps in preventing burnout and maintaining mental and physical health. 4. Build a Supportive Network: Surround yourself with peers who understand your struggles and can offer support. Peer networks and friendtors (friendly mentors) can provide emotional and professional support, making you feel less isolated. 5. Be Kind to Yourself: Practice self-compassion by acknowledging your achievements, setting realistic goals, and allowing yourself to rest. Recognise that it's okay not to be perfect and that your well-being is crucial for long-term success. -- Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you’ll find a video version of this podcast with a transcript on YouTube: https://youtu.be/slPMLjva6Ws -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on social media: http://www.instagram.com/dementia_researcher/ http://www.facebook.com/Dementia.Researcher/ http://twitter.com/demrescommunity http://www.linkedin.com/company/dementia-researcher

A weekly gathering to discuss careers and research topics, inspired by 17th and 18th century salons from Paris, with a modern twist. These sessions combine livestreams, guest speakers and group chat to exchange ideas, challenge, influence, inspire and educate. After the 30 minute livestream ends, you can join the host and speakers with our others and continue to discuss the topic for a further 30 minutes (you will find this in past events). Our very first gathering is scheduled for the 26th June at 12noon BST to explore 'Tackling Sexism in Academia'. Join us LIVE or join our community to catch-up when you have time: https://communities.dementiaresearcher.nihr.ac.uk/c/events/tackling-sexism-in-academia-6284d2d8-3ddc-44f6-a618-8d7a3492f148 -- Sexism in academia is a significant issue that manifests through unequal opportunities, pay disparities, and underrepresentation of women, particularly in senior and leadership roles. Despite advancements in policies aimed at fostering equality, implicit biases and structural barriers continue to impede the progress of female academics. How can we claim to value intellectual diversity when half the population is underrepresented in academic leadership What message are we sending to the next generation of scholars if we continue to ignore the gender biases that permeate our institutions? Can academia truly progress if it fails to address the systemic barriers that prevent women from succeeding at the same rate as their male counterparts? In this salon session we will hear from our speakers and then give you the audience a chance to have your say. Speakers Georgina Menzies - is a Computational Biologist and Lecturer with a research portfolio in understanding DNA-repair and disease modifying coding mutations. Prior to this appointment Georgina held a Ser Cyrmu II Fellowship in the Dementia Research Institute at Cardiff. Georgina is involved in the Alzheimer's Research UK network in South Wales, and has helped drive the ECR steering committee for the UKDRI cross-centre theme on DNA repair and neurodegeneration into existence. Soumilee Chaudhuri - is a 3rd year doctoral candidate in Medical Neuroscience and Bioinformatics at the Indiana University School of Medicine, researching Alzheimer's Disease and Related Dementia (ADRD) in multiethnic populations. Soumilee was raised in Kolkata, India and graduated with double degrees in Neuroscience & Biochemistry from Montana State University, Bozeman as an International Merit Scholar. She works at the intersection of multi-omics and neuroimaging to characterize Alzheimer Disease (AD) therapeutics; she was competitively awarded the Alzheimer's Disease Neuroimaging Initiative Health Equity Scholar Program (ADNI HESP) fellowship. Her interests and experiences range from neurodegenerative diseases, neuroinformatics, to science communication, public health policy and diversifying academia & research spaces. She is the recent co-founder of IMPACT IN (Initiative for Mobilizing Public health Advocacy, Care, and Translational research for Alzheimer’s Disease in Indiana).

Join Dr Sam Moxon and guests, Dr Emily Willroth, Dr Kyrsten Hill, and Karysa Britton, from Washington University in St. Louis three of the people behind the World Happiness Report. Together they discuss their research showing that higher levels of well-being can act as protective factors against dementia and improve the quality of life for those living with the condition. They highlighted the importance of mental health and well-being in dementia prevention and care, and the potential for public health policies and community programs to incorporate these findings. In the show our guests also emphasise the value of interdisciplinary collaboration in tackling dementia prevention. In the 2024 issue of the World Happiness Report, the authors focus on the happiness of people at different stages of life. In the seven ages of man in Shakespeare’s As You Like It, the later stages of life are portrayed as deeply depressing. But happiness research shows a more nuanced picture, and one that is changing over time. In this show we focus on 'Chapter 4 - Supporting the Well-being of an Aging Global Population: Associations between Well-being and Dementia'. However, we encourage you to explore all of the 2024 report for the latest findings on the happiness of the world’s young, the old – and everyone in between. Listen to the postcast, read the report and check where the place you live, sits in the global happiness rankings. Links mentioned in the show: The World Happiness Report 2024 - https://bit.ly/4c2iOrg Country Rankings - https://bit.ly/3KNyraa -- Full biographies on all our guests and a transcript can be found on our website: www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you’ll find a video version of this podcast with a transcript on YouTube: https://youtu.be/HnDcLGEU_5c -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: www.instagram.com/dementia_researcher/ www.facebook.com/Dementia.Researcher/ twitter.com/demrescommunity www.linkedin.com/company/dementia-researcher

In this episode of the Dementia Researcher podcast, Dr Sam Moxon interviews Dr Michael Klaper discussing the impact of diet and nutrition on brain health and dementia. They explore the importance of a plant-based diet, rich in antioxidants and phytonutrients, for maintaining brain health. They also discuss the negative effects of ultra processed foods and animal-based diets on brain health. Dr. Klaper emphasises the importance of sleep, exercise, and stress management for overall brain health. He also suggests practical tips for transitioning to a plant-based diet, such as incorporating more vegetables and legumes into meals and exploring international cuisines. About the guest: Dr Klaper graduated from the University of Illinois College of Medicine in 1972. He served a medical internship at Vancouver General Hospital in British Columbia, received training in surgery, anesthesiology & orthopedics at the University of British Columbia Hospital in Vancouver & trained in obstetrics at the University of California Hospital in San Francisco. Dr Klaper is a clinician, internationally-recognised teacher & speaker on diet & health. In addition to his clinical practice & private consultations with patients, he's a passionate & devoted educator of physicians & other healthcare professionals about the importance of nutrition in clinical practice & integrative medicine. He's also the author of Vegan Nutrition; Pure & Simple & has produced numerous videos, webinars & dozens of articles for both scientific journals & the popular press. As a source of inspiration advocating plant-based diets & the end of animal cruelty worldwide, Dr Klaper contributed to the making of 2 PBS television programs, Food for Thought & the award-winning movie, Diet for a New America. He teaches that “Health Comes From Healthy Living” & is dedicated to the healing & flourishing of all living beings & our planet. He is also a consultant for NASA advising the interplanetary missions on nutrician. -- Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you’ll find a video version of this podcast with a transcript on YouTube: https://youtu.be/zaTYwpPOiqo -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: www.instagram.com/dementia_researcher/ www.facebook.com/Dementia.Researcher/ twitter.com/demrescommunity www.linkedin.com/company/dementia-researcher

This week the Dementia Researcher Podcast shines a spotlight on last months DSAD-ADAD Conference, which focused on Down Syndrome Associated Alzheimer's disease (DSAD) and Autosomal Dominant Alzheimer's Disease (ADAD). The conference, held in Barcelona, brought together over 160 researchers from 16 countries to discuss groundbreaking research in the fight against Alzheimer's disease. The podcast hosted Sára Erzsebet Zsadányi features three guests, Natalie Edwards, Dr Lisi Flores Aguilar, and Professor Jason Hassenstab. Together they share news from the conference and discuss various topics from genetic predispositions to treatment strategies. The conference highlighted the importance of collaboration and the overlap between DSAD and ADAD research. The podcast also touches on the potential of using retinal imaging as a biomarker for Alzheimer's disease, the importance of considering sex and APOE4 homozygotes in research, and the need for more patient perspectives in clinical trials. -- About the guests: Dr Lisi Flores Aguilar is a Postdoctoral Research at University of California, Irvine researching cerebrovascular pathology in people with Down syndrome and Alzheimer’s disease under the mentorship of Dr Elizabeth Head. Natalie Edwards is a PhD Student at Columbia University. Natalie is studying the independent and interactive contributions of cerebrovascular disease and neuroinflammation to Alzheimer’s disease in adults with Down syndrome using neuroimaging techniques and biofluidics. Jason Hassenstab is Professor, Neurology and Psychology at Washington University in St. Louis. Jason directs a lab called the ‘Cognitive Technology Research Laboratory (CTRLab)’ where they develop technology designed to improve the assessment of cognition and function in normal aging and in Alzheimer’s populations. He has also been the Cognition Core Leader for the Dominantly Inherited Alzheimer Network (DIAN) studies for 11 years, and is Principal Investigator of ARC-DS, a multi-site study to develop a mobile data collection platform in Down syndrome-associated Alzheimer’s disease. Sára Erzsebet Zsadányi is a PhD Student at the Sant Pau Memory Unit – Neuroimaging Core and Universitat Autonoma de Barcelona. Originally from New Zealand, Sára studied psychology and linguistics, but always felt really drawn to neuroscience and especially to Alzheimer’s disease. Her research is focused on neuroimaging of small vessel disease in Down Syndrome and autosomal dominant Alzheimer’s disease. -- For more information on the conference visit: https://dsad-adad.com/ -- Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you’ll find a video version of this podcast with full captions on our YouTube Channel: https://youtu.be/RC7a-c1BBs8 -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher

This special episode of the Dementia Researcher Podcast was recorded live in front of an audience at the AAIC Neuroscience Next Conference at Trinity College Dublin. Dr Francesca Farina, a Senior Fellow at University of Chicago and the Global Brain Health Institute at Trinity College in Dublin, hosts a discussion on the topic of ‘leaving home for science’. The guests are Elul Lakew, a clinical psychologist and mental health advocate from Ethiopia, Dr Claudia Suemoto, an Associate Professor of Geriatrics at the University of Sao Paulo Medical School in Brazil, and Muireann Irish, a Professor of Cognitive Neuroscience at the University of Sydney. They discuss the challenges and benefits of moving for work, what motivated them, the importance of mentorship and collaboration, and the impact of cultural differences on their experiences. They also touch on the issue of "academic brain drain" and the potential future of international mobility in research. -- Resources mentioned in the show: Event Recordings for those pre-registered: https://bit.ly/3mEhcPU -- Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you’ll find a video version of this podcast with full captions on our YouTube Channel: https://youtu.be/fuB4Y2KSt94 -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer’s Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: http://www.instagram.com/dementia_researcher/ http://www.facebook.com/Dementia.Researcher/ http://twitter.com/demrescommunity http://www.linkedin.com/company/dementia-researcher #EDI #Equity #Diversity #AcademicCareers